16:10,11 THE FIFTH VIAL.
The fifth angel poured out his vial upon the seat of the beast. By the throne of the beast (Revised Version) must be meant the seat of his power.
16:11 And they - His followers. Gnawed their tongues - Out of furious impatience. Because of their pains and because of their ulcers - Now mentioned together, and in the plural number, to signify that they were greatly heightened and multiplied.
16:8-11 The heart of man is so desperately wicked, that the most severe miseries never will bring any to repent, without the special grace of God. Hell itself is filled with blasphemies; and those are ignorant of the history of human nature, of the Bible, and of their own hearts, who do not know that the more men suffer, and the more plainly they see the hand of God in their sufferings, the more furiously they often rage against him. Let sinners now seek repentance from Christ, and the grace of the Holy Spirit, or they will have the anguish and horror of an unhumbled, impenitent, and desperate heart; thus adding to their guilt and misery through all eternity. Darkness is opposed to wisdom and knowledge, and forebodes the confusion and folly of the idolaters and followers of the beast. It is opposed to pleasure and joy, and signifies anguish and vexation of spirit.
