2:21 {4} And it shall come to pass, [that] whosoever shall {n} call on the name of the Lord shall be saved.
(4) The most important use of all the gifts of the Holy Spirit is to bring men to salvation by faith.
(n) These words call on signify in Holy Scriptures and earnest praying and craving for help from God's hand.
2:21 Whosoever shall call on the name of the Lord, etc. To turn to the Lord for salvation in his appointed way. It means far more than simply prayer. He who would call on the name of the Lord for salvation must do more than say, Lord, Lord, open unto us (Lu 13:25). He must hear and obey (Mt 7:21).
2:21 But - whosoever shall call on the name of the Lord - This expression implies the whole of religion, and particularly prayer uttered in faith; shall be saved - From all those plagues; from sin and hell.
2:14-21 Peter's sermon shows that he was thoroughly recovered from his fall, and thoroughly restored to the Divine favour; for he who had denied Christ, now boldly confessed him. His account of the miraculous pouring forth of the Spirit, was designed to awaken the hearers to embrace the faith of Christ, and to join themselves to his church. It was the fulfilling the Scripture, and the fruit of Christ's resurrection and ascension, and proof of both. Though Peter was filled with the Holy Ghost, and spake with tongues as the Spirit gave him utterance, yet he did not think to set aside the Scriptures. Christ's scholars never learn above their Bible; and the Spirit is given, not to do away the Scriptures, but to enable us to understand, approve, and obey them. Assuredly none will escape the condemnation of the great day, except those who call upon the name of the Lord, in and through his Son Jesus Christ, as the Saviour of sinners, and the Judge of all mankind.