7:6 After this I beheld, and lo another, like a {h} leopard, which had upon the back of it {i} four wings of a fowl; the beast had also four heads; and {k} dominion was given to it.
(h) Meaning Alexander the king of Macedonia.
(i) That is, his four chief captains, which had the empire among them after his death. Selencus had Asia the great, Antigonus the less, Cassander and after him Antipater was king of Macedonia, and Ptolemeus had Egypt.
(k) It was not of himself nor of his own power that he gained all these countries: for his army contained only thirty thousand men, and he overcame in one battle Darius, who had one million, when he was so heavy with sleep that his eyes were hardly open, as the stories report: therefore this power was given to him from God.
7:6 Like a leopard - This leopard was the Grecian monarchy; a leopard is less than a lion, so was this monarchy at first, but yet durst fight with a lion; so did Alexander encounter Darius with an inferior force. A leopard also for his swiftness; therefore described with four wings on his back. Four heads - He was succeeded by four of his chief commanders, who divided that empire into four parts.
7:1-8 This vision contains the same prophetic representations with Nebuchadnezzar's dream. The great sea agitated by the winds, represented the earth and the dwellers on it troubled by ambitious princes and conquerors. The four beasts signified the same four empires, as the four parts of Nebuchadnezzar's image. Mighty conquerors are but instruments of God's vengeance on a guilty world. The savage beast represents the hateful features of their characters. But the dominion given to each has a limit; their wrath shall be made to praise the Lord, and the remainder of it he will restrain.