4:2 Preach the word. Proclaim the Word, as a herald of Christ. This is implied in the Greek. The Word is the Gospel and its teachings. Nothing else must be preached. The excellence of the Scriptures has just been mentioned (2Ti 3:16,17). These equip the preacher for his work.
Be instant in season, out of season. Preach on all occasions. Be urgent in the work.
4:2 Be instant - Insist on, urge these things in season, out of season - That is, continually, at all times and places. It might be translated, with and without opportunity - Not only when a fair occasion is given: even when there is none, one must be made.
4:1-5 People will turn away from the truth, they will grow weary of the plain gospel of Christ, they will be greedy of fables, and take pleasure in them. People do so when they will not endure that preaching which is searching, plain, and to the purpose. Those who love souls must be ever watchful, must venture and bear all the painful effects of their faithfulness, and take all opportunities of making known the pure gospel.